Hardcore players, where death is permanent, must craft Horadric Jewels that prioritize defense, survivability, and sustain. The wrong Jewels can mean the end of your journey, so a thoughtful approach to Infusions and Runes is crucial.

Craft Infusions that provide strong damage mitigation such as Ironclad Infusion, which boosts armor and elemental resistances. These defensive bonuses help mitigate both physical and magical damage sources.

Runes that increase health regeneration, energy shield, or crowd control resistance are invaluable. These Runes increase your ability to Diablo 4 gold survive prolonged fights and recover quickly after damage.

Resource management is also vital; crafting Jewels that reduce resource costs on defensive skills allows you to maintain protective buffs longer.

Choose Jewels that offer life leech or healing over time effects to sustain through damage spikes. Healing Runes that activate on hit or kill are also excellent for regaining lost health.

Hardcore survival also means having escape options. Infusions that reduce cooldowns on mobility or invulnerability skills help avoid fatal damage.

Material farming for hardcore Jewels should focus on safety — gather crafting components in low-risk areas before venturing into dangerous content.

Lastly, keep an eye on your build’s synergy, ensuring boss unique items Jewels complement your defensive setup while not overly sacrificing damage.

With this defense-first approach to Horadric Jewels, hardcore players can enjoy more secure and lasting gameplay in Diablo 4.